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| Biofilm-coated implant By Tan et al. 2020, Sci Adv 6:eaba5723 CC BY-NC 4.0 |
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Show notes:
Microbe of the episode: Methylobacterium organophilum
Takeaways
Skeletal implants make it a lot easier for many people to stay mobile as they age, but the surgical procedure of implanting is risky. Its invasive nature puts stress on the immune system, which puts stress on other systems, and the spread of antibiotic resistance is increasing the risk of a hard-to-treat infection.
In this study, probiotic bacteria grow in a biofilm on titanium implants before being inactivated, leaving only the biofilm behind on the implant. This biofilm-coated implant showed improved bone integration, antimicrobial resistance that was not toxic to the body's own tissues, and reduced inflammation when implanted into rats.
Tan L, Fu J, Feng F, Liu X, Cui Z, Li B, Han Y, Zheng Y, Yeung KWK, Li Z, Zhu S, Liang Y, Feng X, Wang X, Wu S. 2020. Engineered probiotics biofilm enhances osseointegration via immunoregulation and anti-infection. Sci Adv 6:eaba5723.
Other interesting stories:
- Certain gut microbes correlate with lower risk from norovirus (paper)
- Mixture of microbes similar to kombucha engineered to produce living functional materials
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